Understanding how stress and alcohol use affect brain function and behavior
8/8: INIA Stress and Chronic Alcohol Interactions: Cross-species plasticity signatures of alcohol and stress
['FUNDING_U01'] · VANDERBILT UNIVERSITY · NIH-11012902
This study is looking at how stress and thinking skills affect the risk of developing alcohol use problems, using mice to understand which brain cells are involved, with the hope of finding better ways to help people struggling with alcohol issues.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-11012902 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between stress, cognitive function, and alcohol use disorder (AUD). It aims to identify how individual differences in stress reactivity and cognitive deficits contribute to the likelihood of developing AUD. By using advanced techniques to analyze both behavior and brain activity in mice, the study seeks to pinpoint the specific neurons involved in these interactions. This approach will help clarify how these factors influence each other and may lead to more effective treatment strategies for AUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder, particularly those who have experienced stress-related cognitive deficits.
Not a fit: Patients who do not have issues related to alcohol use or stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals struggling with alcohol use disorder by tailoring interventions based on individual cognitive and stress profiles.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between stress and alcohol use, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SICILIANO, CODY — VANDERBILT UNIVERSITY
- Study coordinator: SICILIANO, CODY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder