Understanding how stress and aging affect protein regulation in cells
Post-transcriptional regulations of proteomes in stress and senescence
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-10894250
This study is looking at how our bodies make and change proteins when we're stressed or getting older, and it aims to help us understand how these changes might affect diseases related to aging and stress, so we can find better ways to help people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10894250 on ClinicalTrials.gov |
What this research studies
This research investigates how post-transcriptional mechanisms influence protein expression in response to stress and aging. By utilizing advanced multi-omics techniques, the team aims to analyze how different proteins are produced and modified in various tissues under stress conditions. The study will focus on the roles of alternative splicing and RNA-binding proteins in regulating protein levels and localization, which are crucial for cellular function. Patients may benefit from insights gained about how these processes affect diseases related to aging and stress.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related conditions or those affected by diseases linked to cellular stress.
Not a fit: Patients with acute, non-chronic conditions unrelated to aging or cellular stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and conditions caused by cellular stress.
How similar studies have performed: Previous research has shown promising results in understanding post-transcriptional regulation, indicating that this approach has potential for significant findings.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAM, MAGGIE — UNIVERSITY OF COLORADO DENVER
- Study coordinator: LAM, MAGGIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.