Understanding how stress affects mitochondrial function
Molecular mechanisms of the mitochondrial permeability transition
This study is looking at how stress affects tiny parts of our cells called mitochondria, which are important for making energy, to find new ways to help prevent cell damage and diseases like heart problems and neurodegeneration.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11009957 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that lead to the permeabilization of the mitochondrial inner membrane under stress conditions. Mitochondria are crucial for energy production in cells, and when their function is disrupted, it can result in cell death and various diseases, including heart attacks and neurodegeneration. By studying how stress influences mitochondrial permeability, the research aims to identify potential therapeutic targets to prevent cell dysfunction and death. This could lead to new treatments for conditions related to mitochondrial dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or suffering from conditions related to mitochondrial dysfunction, such as heart disease or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect cells from damage and death in diseases like heart attacks and neurodegenerative disorders.
How similar studies have performed: Previous research has shown that targeting mitochondrial permeability can be beneficial in preventing cell death, indicating a promising avenue for therapeutic development.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Pavlov, Evgeny — New York University
- Study coordinator: Pavlov, Evgeny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.