Understanding how stress affects insulin-producing cells in the pancreas
Official title: Aberrant nuclear signaling in the islet beta cell under metabolic stress
Funded at John D Dingell VA Medical Center · NIH-10927461 · Data updated 2026-11-12
This study is looking at how long-term stress on the body affects the insulin-making cells in the pancreas, which is important for people with diabetes, to help find better ways to treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | John D Dingell VA Medical Center NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006377-01A1 |
| Project ID | NIH-10927461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with adult-onset diabetes or those at risk of developing diabetes due to metabolic stress.
✕Less likely to help
Patients with type 1 diabetes or those whose diabetes is not related to metabolic stress may not benefit from this research.
What this research studies
This research investigates how chronic metabolic stress impacts the function of insulin-producing beta cells in the pancreas. It focuses on the molecular mechanisms that lead to beta cell dysfunction and loss, particularly examining the role of specific proteins involved in cellular signaling. By studying both rodent and human islet cells, the research aims to uncover how stress alters the transport of essential signaling proteins, which could lead to better understanding and potential treatments for diabetes. The approach includes a combination of laboratory experiments and analysis of cellular responses to stress conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving beta cell function and improving diabetes management.
How similar studies have gone: While the specific focus on nucleocytoplasmic shuttling in beta cells under metabolic stress is novel, related research has shown promising results in understanding beta cell dysfunction.
Where this research is happening
-
John D Dingell VA Medical Center
Detroit, United States Active
Researchers
- Principal investigator: Kowluru, Anjaneyulu — John D Dingell VA Medical Center
- Study coordinator: Kowluru, Anjaneyulu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.