Understanding how stress affects insulin-producing cells in diabetes
Official title: BLRD Research Career Scientist Award Application
Funded at John D Dingell VA Medical Center · NIH-10948091 · Data updated 2026-11-12
This study is looking at how stress affects insulin-producing cells in the body, which is important for understanding diabetes, and aims to find ways to help these cells stay healthy and improve diabetes treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | John D Dingell VA Medical Center NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | October 1, 2020 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5IK6BX005383-05 |
| Project ID | NIH-10948091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who are experiencing or at risk for adult-onset diabetes.
✕Less likely to help
Patients who do not have diabetes or are not veterans may not benefit from this research.
What this research studies
This research investigates the cellular and molecular mechanisms that lead to dysfunction in insulin-producing beta cells, which is crucial for the onset of diabetes. The principal investigator has nearly 30 years of experience in diabetes research and is focusing on how metabolic stress activates a protein called Rac1, which may cause damage to these cells. By using advanced techniques such as microscopy and molecular biology, the team aims to identify key factors that could help improve the health of beta cells and ultimately diabetes treatment. The research primarily uses animal models to explore these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating diabetes.
How similar studies have gone: Previous research has shown promising results in understanding beta cell dysfunction, making this approach both relevant and potentially impactful.
Where this research is happening
-
John D Dingell VA Medical Center
Detroit, United States Active
Researchers
- Principal investigator: Kowluru, Anjaneyulu — John D Dingell VA Medical Center
- Study coordinator: Kowluru, Anjaneyulu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.