Understanding how stress affects herpesvirus infections
Interplay between nuclear stress responses and herpesvirus latency
This study is looking at how the herpes virus can hide in nerve cells and what makes it wake up during stressful times, with the hope of finding ways to keep it from causing problems for people with herpes infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10983350 on NIH RePORTER |
What this research studies
This research investigates how the herpes simplex virus-1 (HSV1) can remain dormant in neurons and what triggers its reactivation during times of physiological stress. By using advanced techniques to study primary neurons, the researchers aim to uncover the molecular mechanisms that allow the virus to stay latent and how stress responses can disrupt this state. The goal is to identify specific neuronal factors that can inhibit the virus's ability to replicate when it is reactivated. This work could lead to new insights into managing herpesvirus infections and their impact on neurological health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of herpes simplex virus infections, particularly those experiencing recurrent outbreaks triggered by stress.
Not a fit: Patients without a history of herpes simplex virus infections or those who do not experience stress-related outbreaks may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing herpesvirus reactivation, potentially reducing the incidence of outbreaks and associated complications.
How similar studies have performed: Previous research has shown promising results in understanding viral latency and reactivation, suggesting that this approach could yield valuable insights into herpesvirus behavior.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Wilson, Angus C — New York University School of Medicine
- Study coordinator: Wilson, Angus C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.