Understanding how stress affects herpesvirus infections
Official title: Interplay between nuclear stress responses and herpesvirus latency
Funded at New York University School of Medicine · NIH-10983350 · Data updated 2026-11-12
This study is looking at how the herpes virus can hide in nerve cells and what makes it wake up during stressful times, with the hope of finding ways to keep it from causing problems for people with herpes infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | November 8, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $656,955 |
| NIH project number | 5R01AI176335-02 |
| Project ID | NIH-10983350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of herpes simplex virus infections, particularly those experiencing recurrent outbreaks triggered by stress.
✕Less likely to help
Patients without a history of herpes simplex virus infections or those who do not experience stress-related outbreaks may not benefit from this research.
What this research studies
This research investigates how the herpes simplex virus-1 (HSV1) can remain dormant in neurons and what triggers its reactivation during times of physiological stress. By using advanced techniques to study primary neurons, the researchers aim to uncover the molecular mechanisms that allow the virus to stay latent and how stress responses can disrupt this state. The goal is to identify specific neuronal factors that can inhibit the virus's ability to replicate when it is reactivated. This work could lead to new insights into managing herpesvirus infections and their impact on neurological health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing herpesvirus reactivation, potentially reducing the incidence of outbreaks and associated complications.
How similar studies have gone: Previous research has shown promising results in understanding viral latency and reactivation, suggesting that this approach could yield valuable insights into herpesvirus behavior.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Wilson, Angus C — New York University School of Medicine
- Study coordinator: Wilson, Angus C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.