Understanding how stress affects cocaine addiction relapse
The Role of Prelimbic Corticotrophin Releasing Factor Type 1 Receptor and L-Type Calcium Channels in Stress-induced Relapse
This study is looking at how stress can cause cravings for cocaine in people trying to stay sober, with the goal of finding new ways to help prevent relapse and improve treatment options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11070442 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that lead to relapse in individuals with cocaine use disorder, particularly focusing on the role of specific receptors and calcium channels in the brain. By examining how stress triggers cravings during abstinence, the study aims to identify potential targets for new treatments. The research will utilize advanced techniques to analyze genetic variants and their impact on brain function related to addiction. Patients may benefit from insights that could lead to more effective therapies for preventing relapse.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cocaine use disorder who are experiencing challenges with relapse, especially under stress.
Not a fit: Patients who are not struggling with cocaine addiction or those who have not experienced relapse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals struggling with cocaine addiction, particularly in managing stress-related cravings.
How similar studies have performed: Previous studies have shown promise in understanding the role of specific receptors in addiction, but this particular focus on the prelimbic cortex and its relation to stress-induced relapse is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Uchendu, Stacy Ndidi — Yale University
- Study coordinator: Uchendu, Stacy Ndidi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.