Understanding how Streptococcus mutans sticks to teeth and other microbes
The Structural and Functional Determination of Streptococcus mutans Adherence
This study looks at how a common bacteria called Streptococcus mutans sticks to teeth and forms harmful layers that can cause cavities, especially in kids, with the goal of finding better ways to prevent and treat tooth decay.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10788286 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the bacteria Streptococcus mutans adheres to tooth surfaces and forms biofilms, which are critical in the development of dental caries, especially in children. The study focuses on the interactions between S. mutans and host proteins, as well as its relationship with other microorganisms like Candida albicans. By exploring the specific binding motifs and molecular mechanisms involved, the research aims to uncover new insights into how these bacteria contribute to tooth decay. This could lead to better prevention and treatment strategies for dental caries in young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are at risk for dental caries.
Not a fit: Patients who are adults or do not have a history of dental caries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing and treating dental caries in children.
How similar studies have performed: Previous research has shown success in understanding bacterial adhesion mechanisms, but this specific focus on S. mutans and its interactions is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Deivanayagam, Champion Christdoss Selvakumar — University of Alabama at Birmingham
- Study coordinator: Deivanayagam, Champion Christdoss Selvakumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.