Understanding how STING affects inflammation and immune responses
Mechanisms of STING-associated autoinflammation
This study is looking at how a protein called STING affects the immune system and can lead to autoinflammatory diseases, with the goal of finding better ways to understand and treat conditions like STING-associated vasculopathy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11056885 on NIH RePORTER |
What this research studies
This research investigates the role of the STING protein in causing autoinflammatory diseases, particularly focusing on how it influences immune cell behavior and cytokine release. By utilizing advanced animal models, the study aims to uncover specific functions of STING in various immune cells, including macrophages and innate lymphoid cells. The researchers have previously identified unexpected pathways in STING-related diseases and are now exploring how these mechanisms can lead to better understanding and potential treatments for conditions like STING-associated vasculopathy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with STING-associated vasculopathy or other related autoinflammatory disorders.
Not a fit: Patients with non-autoinflammatory conditions or those not affected by STING-related pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from autoinflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding STING's role in inflammation, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Miner, Jonathan J — University of Pennsylvania
- Study coordinator: Miner, Jonathan J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.