Understanding how steroid hormones affect the growth of uterine fibroids
Steroid Receptor Crosstalk and Pathogenesis of Uterine Fibroids
This study is looking into how certain hormones affect the growth of uterine fibroids, which are common non-cancerous tumors in women, to find new, less invasive treatment options that could help those dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10854730 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind the development and growth of uterine fibroids, which are common benign tumors in women. The study focuses on how glucocorticoid receptors interact with estrogen and progesterone receptors to influence fibroid cell proliferation. By exploring these pathways, the research aims to identify new therapeutic options that could provide non-invasive treatments for women suffering from fibroids. Patients may benefit from a better understanding of their condition and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who are experiencing symptoms related to uterine fibroids.
Not a fit: Patients who do not have uterine fibroids or are post-menopausal may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, non-invasive treatment options for women suffering from uterine fibroids.
How similar studies have performed: Other research has shown promising results in understanding hormone interactions in tumors, suggesting potential for success in this area as well.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Whirledge, Shannon D — Yale University
- Study coordinator: Whirledge, Shannon D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.