Understanding how steroid hormones activate a specific receptor in the brain
Official title: GPR123 Activation by Steroid Ligands
Funded at Emory University · NIH-11119853 · Data updated 2026-11-12
This study is looking at how certain hormones in your body interact with a brain receptor called GPR123, and it hopes to find new ways to help treat metabolic disorders and other health issues related to these hormones.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $234,750 |
| NIH project number | 1R21NS142860-01 |
| Project ID | NIH-11119853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with metabolic disorders or conditions influenced by steroid hormones.
✕Less likely to help
Patients who do not have metabolic disorders or related hormonal issues may not benefit from this research.
What this research studies
This research investigates how steroid hormones influence various bodily functions by activating a receptor known as GPR123, which is primarily found in the brain. The study aims to identify how these hormones bind to GPR123 and how this interaction triggers rapid cellular responses. By exploring the signaling pathways involved, the research seeks to uncover new therapeutic targets for treating metabolic disorders and other diseases linked to steroid hormone activity.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders and improve our understanding of steroid hormone functions.
How similar studies have gone: Other research has shown promise in understanding G protein-coupled receptors and their roles in cellular signaling, suggesting potential for success in this area.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Hall, Randy a. — Emory University
- Study coordinator: Hall, Randy a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.