Understanding how stem cells help maintain male fertility
Spermatogonial stem cell regulation and maintenance of male fertility
This study is looking at how certain cells in the testes help make sperm, using zebrafish to understand the environment they need to thrive, and the goal is to find new ways to help men who have trouble producing sperm.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10360087 on NIH RePORTER |
What this research studies
This research investigates the role of spermatogonial stem cells (SSCs) in male fertility, particularly focusing on how these cells produce sperm. The study uses zebrafish as a model to explore the complex environment that supports SSCs, including various testicular cell types and circulating factors. By examining the regulatory mechanisms that control SSC maintenance and differentiation, the research aims to uncover critical insights into male infertility. Patients may benefit from findings that could lead to new treatments for those struggling with sperm production.
Who could benefit from this research
Good fit: Ideal candidates for this research are men experiencing infertility issues related to low sperm production.
Not a fit: Patients who have infertility due to non-male factors or those with complete absence of sperm production may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for male infertility, improving the chances of conception for couples affected by this issue.
How similar studies have performed: Other research has shown promise in understanding stem cell regulation in fertility, but this specific approach using zebrafish is relatively novel.
Where this research is happening
Boston, United States
- University of Massachusetts Boston — Boston, United States (Active)
Researchers
- Principal investigator: Siegfried, Kellee R — University of Massachusetts Boston
- Study coordinator: Siegfried, Kellee R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.