Understanding how stem cells develop into germ cells
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10828318
This study is looking at how stem cells turn into germ cells, which are important for reproduction, and it aims to understand how certain proteins help control this process, so it could eventually help people dealing with infertility or related health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10828318 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular and cellular mechanisms that control the differentiation of stem cells into germ cells, which are essential for reproduction. By focusing on epigenetic regulation, the study aims to uncover how certain proteins influence stem cell behavior, including their ability to self-renew and differentiate properly. The research utilizes advanced techniques such as ChIP sequencing to analyze gene expression changes without altering DNA sequences. Patients may benefit from insights gained in this research, particularly in areas related to infertility and various diseases linked to stem cell dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals experiencing infertility or conditions related to stem cell dysfunction.
Not a fit: Patients with conditions unrelated to stem cell differentiation or those who are not experiencing fertility issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for infertility and other diseases caused by stem cell imbalances.
How similar studies have performed: Other research has shown promising results in understanding stem cell differentiation and its implications for treating infertility and related diseases.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, XIN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CHEN, XIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancers