Understanding how stem cells decide their fate in epithelial tissues
Cell Fate Decisions in Epithelial Stem Cell Lineages
This study is looking at how certain stem cells in our bodies change into different types of cells, which is important for keeping tissues healthy, and it uses fruit flies and mice to understand the signals and interactions that guide these changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11087904 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control how epithelial stem cells differentiate into various cell types within continuously renewing tissues. By using advanced techniques to observe cell behaviors in their natural environments, the study focuses on model systems like the Drosophila ovary and mouse intestinal stem cells. The research aims to uncover the roles of specific signaling pathways and cellular interactions that influence stem cell behavior and fate decisions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to epithelial tissue dysfunction or those interested in stem cell therapies.
Not a fit: Patients with non-epithelial related conditions or those not interested in stem cell research may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for regenerative medicine and cancer treatment by enhancing our understanding of stem cell behavior.
How similar studies have performed: Previous research has shown success in understanding stem cell behavior through similar approaches, indicating a promising avenue for further exploration.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Nystul, Todd — University of California, San Francisco
- Study coordinator: Nystul, Todd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.