Understanding how stem cells age
Molecular Regulation of Stem Cell Aging
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11103174
This research explores why muscle stem cells lose their ability to repair tissues as we get older, hoping to find ways to keep them young and active.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11103174 on ClinicalTrials.gov |
What this research studies
As we age, our body's ability to heal and regenerate often declines, partly because our tissue-specific stem cells become less effective. This project focuses on muscle stem cells, which are crucial for repairing muscle injuries, and how their function decreases with age. We aim to uncover the specific molecular changes within these cells that make them less responsive over time. By understanding these fundamental mechanisms of aging and how to rejuvenate stem cells, we hope to develop new strategies to restore youthful repair capabilities to aged tissues.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this work may seek older adults experiencing age-related muscle decline or injury.
Not a fit: Patients not experiencing age-related muscle decline or those with conditions unrelated to stem cell function may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help older adults maintain stronger muscles and recover better from injuries by restoring the function of their stem cells.
How similar studies have performed: While the decline of stem cell function with age is well-documented, the molecular basis for reversing this process is still being actively explored and is a novel area of focus for intervention.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RANDO, THOMAS A. — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: RANDO, THOMAS A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.