Understanding How Stem Cells Age
Molecular Regulation of Stem Cell Aging
This project aims to understand why our body's stem cells lose their ability to repair and renew tissues as we get older.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11103159 on NIH RePORTER |
What this research studies
As we age, our body's ability to heal and regenerate can slow down, often because our stem cells don't work as well. This project explores the tiny, molecular changes that happen in stem cells over time, including changes in their genes and how they use energy. We believe that understanding these changes could help us find ways to make aged stem cells work better, potentially restoring youthful repair abilities to tissues. The team is also looking at how factors in the blood and the environment around stem cells might influence their aging process, and how these changes might select for less effective stem cells.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the biology of aging and future therapies that could improve tissue repair and regeneration in older adults.
Not a fit: Patients seeking immediate clinical treatments for age-related conditions would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that slow down, stop, or even reverse the decline in stem cell function, helping tissues stay healthy and repair themselves better as we age.
How similar studies have performed: This program builds upon existing innovative work from the participating laboratories, suggesting a foundation of prior success and novel approaches in understanding stem cell aging.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Rando, Thomas a. — University of California Los Angeles
- Study coordinator: Rando, Thomas a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.