Understanding how stem cell products can help brain recovery after injury in older monkeys
Mechanisms underlying extracellular vesicle mediated changes in inflammation, neural circuitry and plasticity following cortical injury in aged monkeys
This study is looking at how tiny particles from special stem cells can help older people recover from brain injuries by reducing inflammation and supporting healing, using aged monkeys to learn more about how this works and what it could mean for new treatments for brain issues as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10873106 on NIH RePORTER |
What this research studies
This research investigates the role of extracellular vesicles derived from mesenchymal stem cells in promoting recovery from brain injuries, particularly in aged individuals. By studying aged monkeys that have experienced cortical injuries, the research aims to uncover how these stem cell products can reduce inflammation and support brain repair. The approach includes analyzing changes in brain tissue and blood samples to understand the mechanisms of recovery at different stages post-injury. The findings could lead to new treatments for cognitive and motor deficits associated with aging and neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced brain injuries or are suffering from Alzheimer's disease and related dementias.
Not a fit: Patients with acute brain injuries who are not aged or those without neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance recovery from brain injuries and improve cognitive function in older adults.
How similar studies have performed: Previous studies have shown promising results with mesenchymal stem cell therapies in enhancing recovery from brain injuries, indicating potential for success in this research.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Moore, Tara L — Boston University Medical Campus
- Study coordinator: Moore, Tara L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.