Understanding how Staphylococcus bacteria cause eye infections
Staphylococcus Biology in Ocular Infections
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-10898708
This study is looking into how the bacteria Staphylococcus aureus causes serious eye infections that can lead to blindness, with the goal of finding better ways to treat and prevent these infections for people who are affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10898708 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which Staphylococcus aureus leads to serious eye infections, such as keratitis and endophthalmitis, which can result in blindness. The study focuses on how the bacteria attach to eye tissues, trigger inflammation, and produce toxins that damage the eye. By using animal models and cell cultures, researchers aim to uncover the early events in these infections that have not been thoroughly studied. This knowledge could help in developing better treatments and preventive measures for patients suffering from bacterial eye infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of bacterial eye infections or those at high risk for such infections.
Not a fit: Patients with non-bacterial eye conditions or those who do not have any risk factors for bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bacterial eye infections, potentially reducing the risk of vision loss.
How similar studies have performed: Previous research has shown success in understanding bacterial infections in other contexts, but this specific focus on Staphylococcus aureus in ocular infections is relatively novel.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CALLEGAN, MICHELLE C — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: CALLEGAN, MICHELLE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.