Understanding how Staphylococcus aureus produces certain harmful peptides
Official title: Post-translational regulation of alpha PSM production in Staphylococcus aureus by the small RNA Teg41
Funded at Ohio University Athens · NIH-10684260 · Data updated 2026-11-12
This study is looking at how a type of bacteria called Staphylococcus aureus makes certain substances that can make infections worse, especially in strains that don't respond to regular antibiotics, with the hope of finding new ways to treat these tough infections and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $410,424 |
| NIH project number | 5R01AI143743-05 |
| Project ID | NIH-10684260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with infections caused by Staphylococcus aureus, particularly those resistant to methicillin.
✕Less likely to help
Patients with infections caused by other types of bacteria or those not infected with Staphylococcus aureus may not receive any benefit from this research.
What this research studies
This research investigates the production of specific peptides by the Staphylococcus aureus bacteria, which can cause serious infections. The focus is on understanding the molecular mechanisms that regulate the levels of these peptides, particularly in strains that are resistant to common antibiotics. By examining how these peptides are produced and regulated, the research aims to uncover potential targets for new treatments. Patients may benefit from insights that could lead to better management of infections caused by this dangerous pathogen.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by antibiotic-resistant Staphylococcus aureus.
How similar studies have gone: While the specific focus on post-translational regulation of αPSM production is novel, previous research has shown that understanding bacterial virulence factors can lead to successful treatment strategies.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Carroll, Ronan — Ohio University Athens
- Study coordinator: Carroll, Ronan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.