Understanding how Staphylococcus aureus affects immune responses in the skin
Mechanisms of Staphylococcus aureus-induced changes in cutaneous T cell networks
['FUNDING_OTHER'] · IOWA CITY VA MEDICAL CENTER · NIH-11109688
This study is looking at how a common skin infection caused by Staphylococcus aureus affects the immune system, especially in people who have recovered from MRSA infections, to find ways to help the body fight off future infections and possibly develop a vaccine.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | IOWA CITY VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11109688 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacteria Staphylococcus aureus, which commonly causes skin infections, alters the immune system's T cell networks. By examining the immune responses in patients who have healed from MRSA skin infections, the study aims to identify protective mechanisms and potential vaccine targets. The approach includes using models of previous infections to understand how the body can develop immunity against future infections. This could lead to new strategies for preventing severe infections caused by drug-resistant strains.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced skin infections caused by Staphylococcus aureus, particularly those with a history of MRSA infections.
Not a fit: Patients who have not had any history of skin infections or those with compromised immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines against Staphylococcus aureus infections, reducing the incidence of severe skin and soft tissue infections.
How similar studies have performed: Previous research has shown promise in developing vaccines targeting Staphylococcus aureus, indicating that this approach has potential for success.
Where this research is happening
IOWA CITY, UNITED STATES
- IOWA CITY VA MEDICAL CENTER — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARLET, COREY — IOWA CITY VA MEDICAL CENTER
- Study coordinator: PARLET, COREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.