Understanding how stac proteins affect calcium channels in brain cells
Tuning of CaV channel dynamics by stac proteins
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10673110
This study is looking at how certain proteins called stac proteins help control calcium levels in brain cells that are important for movement, which can be affected in Parkinson's disease, with the hope of finding new ways to help manage the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10673110 on ClinicalTrials.gov |
What this research studies
This research investigates the role of stac proteins in regulating calcium channels in dopaminergic neurons, which are crucial for movement control and are affected in Parkinson's disease. By using advanced molecular tools and techniques like electrophysiology, the study aims to uncover how stac proteins influence calcium dynamics and neuronal pacemaking. The findings could provide insights into the mechanisms of neuronal vulnerability in Parkinson's disease and potentially lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those experiencing motor symptoms related to dopaminergic neuron degeneration.
Not a fit: Patients with Parkinson's disease who do not have significant dopaminergic neuron involvement or those with other neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect dopaminergic neurons and improve outcomes for patients with Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding calcium channel dynamics in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNY, MANU BEN — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: JOHNY, MANU BEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.