Understanding how splicing regulation evolves in mammals
Complexity and evolution of splicing-regulatory networks
This study looks at how our genes can create different versions of themselves, which is important for how our bodies work, and it’s for anyone curious about how tiny changes in our DNA can affect our evolution, especially in humans and chimpanzees.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10885128 on NIH RePORTER |
What this research studies
This research investigates how alternative splicing (AS) generates different transcript forms from single genes, which is crucial for the complexity of mammalian biology. It focuses on the role of RNA-binding proteins in regulating AS and explores how mutations in regulatory sequences can drive evolutionary changes in splicing patterns. By developing computational methods and experimental models, the research aims to identify specific AS events that have been subject to adaptive selection in various mammalian lineages, including humans and chimpanzees.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders related to splicing abnormalities or those with a family history of such conditions.
Not a fit: Patients with conditions unrelated to genetic splicing or those not affected by genetic diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic diseases linked to splicing abnormalities and lead to new therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding splicing regulation, suggesting that this approach could yield significant insights into genetic variation and disease.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Zhang, Chaolin — Columbia University Health Sciences
- Study coordinator: Zhang, Chaolin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.