Understanding how splicing in cells can be regulated and evolved
Structure, regulation, and evolution of the splicing machinery
This study is looking at how our cells make important changes to RNA, which can go wrong in diseases like cancer, and aims to find new ways to fix these issues to help improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-11060964 on NIH RePORTER |
What this research studies
This research investigates the complex process of RNA splicing, which is crucial for gene expression and can be altered in diseases like cancer. The team will explore how specific components of the splicing machinery interact and how these interactions can be engineered to improve treatment outcomes. By using innovative techniques, including RNA sequencing and biochemical tests, the research aims to uncover mechanisms that could lead to new therapeutic strategies for diseases associated with splicing errors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers linked to splicing abnormalities.
Not a fit: Patients with conditions unrelated to RNA splicing or those who do not have genetic mutations affecting splicing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by splicing errors, potentially improving patient outcomes.
How similar studies have performed: Other research has shown promising results in manipulating splicing mechanisms, indicating potential for success in this area.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Ares, Manuel — University of California Santa Cruz
- Study coordinator: Ares, Manuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.