Understanding how splicing factors are regulated in cells
Mechanisms of post-transcriptional regulation of splicing factors
This study is looking at how certain proteins that help with gene processing are controlled in our cells, especially in relation to cancer, and it hopes to find new ways to treat diseases caused by problems with these proteins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10825431 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which splicing factors, which are proteins that help control the process of RNA splicing, are regulated in cells. It focuses on a specific family of splicing factors known as serine/arginine-rich proteins and their regulation through non-coding sequences called poison-exons. By using advanced techniques like CRISPR/Cas9 and splicing reporter minigenes, the research aims to uncover how these regulatory mechanisms impact gene expression and contribute to various diseases, particularly cancers. The findings could lead to new therapeutic strategies targeting splicing factor dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers or other conditions associated with splicing factor abnormalities.
Not a fit: Patients with conditions unrelated to splicing factor dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and other diseases linked to splicing factor dysregulation.
How similar studies have performed: Other research has shown promising results in understanding splicing factors and their roles in diseases, indicating that this approach has potential for success.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Anczukow-Camarda, Olga — Jackson Laboratory
- Study coordinator: Anczukow-Camarda, Olga
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.