Understanding how spinal neurons help recover bladder function after spinal cord injury
Plasticity of spinal L3 propriospinal neurons in urination recovery after thoracic SCI
This study is looking at how certain nerve cells in the spine can help people with spinal cord injuries regain control over their bladder, making it easier to urinate.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10575973 on NIH RePORTER |
What this research studies
This research investigates the role of specific spinal neurons in recovering bladder function following a spinal cord injury (SCI). It focuses on understanding how these neurons can help restore the ability to relax the external urethral sphincter, which is crucial for urination. The researchers will use advanced techniques, including electrical stimulation and optogenetics, to explore the connections between these neurons and bladder control. By studying these mechanisms, the research aims to identify potential therapeutic targets for improving bladder function in SCI patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a thoracic spinal cord injury and are facing challenges with bladder function.
Not a fit: Patients with spinal cord injuries at levels other than thoracic or those without bladder dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve bladder control for individuals with spinal cord injuries.
How similar studies have performed: Previous research has shown promise in using electrical stimulation to enhance bladder function recovery in spinal cord injury models, indicating that this approach may be effective.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Deng, Lingxiao — Indiana University Indianapolis
- Study coordinator: Deng, Lingxiao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.