Understanding how spinal neurons change after spinal cord injury
The organization of spinal neurons following spinal cord injury
['FUNDING_R01'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-11034100
This study is looking at how nerve cells in the spinal cord change and adapt after a spinal cord injury, with the goal of finding better ways to help people recover and move better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11034100 on ClinicalTrials.gov |
What this research studies
This research investigates the changes that occur in spinal neurons following a spinal cord injury (SCI), focusing on how these neurons reorganize and adapt in response to the injury. By using advanced techniques such as intraspinal microelectrode arrays, researchers will record the activity of spinal interneurons and motoneurons to understand their interactions and how they affect muscle movement. The study aims to quantify the excitatory and inhibitory connections between these neurons, providing insights into the underlying mechanisms of motor control after SCI. This could lead to improved therapeutic strategies for enhancing recovery and function in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a spinal cord injury and are seeking ways to enhance their recovery and motor function.
Not a fit: Patients with spinal cord injuries who are not experiencing significant motor deficits or those who have had their injuries for an extended period may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve motor function and quality of life for individuals with spinal cord injuries.
How similar studies have performed: Previous research has shown promising results in understanding neuronal reorganization after spinal cord injuries, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMPSON, CHRISTOPHER KEITH — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: THOMPSON, CHRISTOPHER KEITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.