Understanding how spinal cord neurons generate and control movement rhythms
Official title: Mechanisms of rhythm generation and recruitment in mammalian locomotor-related spinal interneurons
Funded at Drexel University · NIH-10933435 · Data updated 2026-11-12
This study is looking at how certain nerve cells in the spinal cord help control movement, which could lead to new treatments for people with paralysis from injuries.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2023 |
| Project end | September 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS132514-02 |
| Project ID | NIH-10933435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect locomotion, such as spinal cord injuries or traumatic brain injuries.
✕Less likely to help
Patients with non-neurological conditions or those who do not experience movement-related issues may not benefit from this research.
What this research studies
This research investigates the mechanisms by which specific spinal cord neurons, known as Shox2 interneurons, generate rhythmic patterns essential for locomotion. By using advanced techniques like whole cell patch clamp electrophysiology and transsynaptic tract tracing, the study aims to uncover how these neurons are activated and coordinated by higher brain centers. The findings could provide insights into the underlying circuitry of movement and potential therapeutic targets for conditions that lead to paralysis, such as spinal cord injuries and traumatic brain injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for paralysis and improve rehabilitation strategies for affected patients.
How similar studies have gone: While the specific mechanisms being studied may be novel, similar research approaches have shown promise in understanding neuronal circuitry and developing treatments for movement disorders.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Singh, Shayna — Drexel University
- Study coordinator: Singh, Shayna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.