Understanding how spinal cord neurons coordinate body movement
Longitudinal structure of spinal premotor circuits
This study is looking at how certain nerve cells in the spinal cord of baby zebrafish work together to help control movement, which could lead to better understanding and treatments for people with movement disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11005018 on NIH RePORTER |
What this research studies
This research investigates the long-range circuits of spinal neurons that are crucial for coordinating movement in animals. By using advanced techniques like optogenetic activation and whole-cell recording, the researchers aim to map how different spinal neuron populations interact and change their connections as they ascend or descend in the spinal cord. The study focuses on specific neuron types in larval zebrafish, which serve as a model to understand these complex neural circuits. Patients may benefit from insights gained about spinal cord function and potential treatments for movement disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with movement disorders or spinal cord injuries.
Not a fit: Patients with conditions unrelated to spinal cord function or movement coordination may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating movement disorders by enhancing our understanding of spinal cord neuron interactions.
How similar studies have performed: Other research has shown success in mapping neural circuits in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Bagnall, Martha W — Washington University
- Study coordinator: Bagnall, Martha W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.