Understanding how spinal cord injuries affect the immune system's ability to fight infections.
SCI-induced deficits in antiviral immunity: The role of sTNF.
This study is looking at how spinal cord injuries can weaken the immune system, making it harder for patients to fight off serious infections like the flu and pneumonia, and it aims to find ways to improve immune responses for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10657427 on NIH RePORTER |
What this research studies
This research investigates how spinal cord injuries (SCI) lead to weakened immune responses, making patients more susceptible to severe infections like influenza and pneumonia. The team aims to uncover the mechanisms behind this immune dysfunction, particularly focusing on the role of soluble Tumor Necrosis Factor (sTNF) in the spinal cord. By studying the changes in immune cell behavior and communication after SCI, the researchers hope to identify potential therapeutic targets to enhance immune function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic spinal cord injuries who are at risk for infections.
Not a fit: Patients without spinal cord injuries or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance immune responses in patients with spinal cord injuries, reducing their risk of life-threatening infections.
How similar studies have performed: Previous studies have shown promising results in understanding immune dysfunction related to spinal cord injuries, indicating that this research builds on established findings.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Tom, Veronica Jean — Drexel University
- Study coordinator: Tom, Veronica Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.