NIH-funded research R01 grant

Understanding how spinal cord injuries affect nerve recovery.

Official title: Propriospinal Plasticity and Recovery After Incomplete Spinal Cord Injury.

Funded at University of Louisville · NIH-11223778 · Data updated 2026-11-12

This study is looking at how certain nerve cells in the spinal cord change after an injury and how those changes can affect recovery, with the goal of finding better ways to help people heal from spinal cord injuries.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Louisville
NIH-funded
Lab location1 site (Louisville, United States)
Project startJune 3, 2025
Project endMay 31, 2030
Funding year2025
Award (this year)$462,296
NIH project number1R01NS141156-01A1
Project IDNIH-11223778 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals aged 21 and older who have experienced an incomplete spinal cord injury.

Less likely to help

Patients with complete spinal cord injuries or those under 21 years old may not benefit from this research.

What this research studies

This research investigates how certain neurons in the spinal cord change after an injury and how these changes can either help or hinder recovery. By using advanced techniques to trace and silence specific spinal cord neurons in animal models, the study aims to link anatomical changes to functional outcomes. The researchers will analyze the anatomy of these neurons before and after different types of spinal cord injuries, using innovative imaging methods and locomotor analysis to assess recovery. This approach could provide insights into improving rehabilitation strategies for individuals with spinal cord injuries.

Why it matters

Potential benefit: If successful, this research could lead to new therapies that enhance recovery after spinal cord injuries.

How similar studies have gone: Previous research has shown promise in understanding spinal cord plasticity, but this specific approach is relatively novel.

Where this research is happening

  • University of Louisville
    Louisville, United States
    Active

Researchers

  • Principal investigator: Magnuson, David Sk — University of Louisville
  • Study coordinator: Magnuson, David Sk

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.