Understanding how spinal cord injuries affect brain communication
Brain-wide transcriptional profiling after spinal cord injury
['FUNDING_R21'] · MARQUETTE UNIVERSITY · NIH-10827193
This study is looking at how spinal cord injuries affect the way the brain and spinal cord communicate, which can cause problems with movement and feeling, and it's using mice to learn more about how certain brain cells respond to injury and how a specific protein might help them heal.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MARQUETTE UNIVERSITY (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10827193 on ClinicalTrials.gov |
What this research studies
This research investigates how spinal cord injuries disrupt communication between the brain and spinal cord, which can lead to various functional challenges such as loss of movement, sensation, and autonomic functions. Using a mouse model, the researchers will analyze gene expression patterns in different types of neurons after spinal cord injury to understand how these cells respond to damage. They will also explore the effects of a specific transcription factor, Sox11, on neuron repair and survival. This comprehensive profiling aims to uncover the cellular mechanisms involved in spinal cord injury recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced spinal cord injuries and are facing challenges related to movement, sensation, or autonomic functions.
Not a fit: Patients with spinal cord injuries who are not experiencing significant functional deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and function for individuals with spinal cord injuries.
How similar studies have performed: Other research has shown promise in understanding cellular responses to spinal cord injuries, but this specific approach using advanced sequencing technologies is relatively novel.
Where this research is happening
MILWAUKEE, UNITED STATES
- MARQUETTE UNIVERSITY — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLACKMORE, MURRAY G — MARQUETTE UNIVERSITY
- Study coordinator: BLACKMORE, MURRAY G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.