Understanding how spinal cord cells affect bladder pain and function
Elucidating Roles of Distinct Spinal Cord Cell types in Mediating Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10945850
This study is looking at how different types of cells in the spinal cord help process bladder pain and function in people with interstitial cystitis/bladder pain syndrome, with the hope of finding better treatments for those who suffer from this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10945850 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of different spinal cord cell types in processing sensations related to bladder pain and function in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). By using advanced techniques like chemogenetics and optogenetics, the study aims to identify how specific spinal cells contribute to bladder discomfort and urinary issues. The research will also explore how these signals are transmitted to various brain regions, providing insights into the underlying mechanisms of this painful condition. Ultimately, the goal is to enhance our understanding of spinal circuits involved in IC/BPS, which could lead to new treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with interstitial cystitis or bladder pain syndrome experiencing chronic bladder pain and urinary dysfunction.
Not a fit: Patients without a diagnosis of interstitial cystitis or bladder pain syndrome are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of innovative therapies that alleviate bladder pain and improve urinary function for patients with IC/BPS.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown promise in understanding spinal cord mechanisms related to pain, suggesting potential for success.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAMINENI, VIJAY K — WASHINGTON UNIVERSITY
- Study coordinator: SAMINENI, VIJAY K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.