Understanding how spinal circuits transmit and regulate visceral pain.
Spinal Circuit Mechanisms of Visceral Sensory Transmission and Regulation
This study is looking at how certain nerve cells in the spinal cord affect belly pain, especially for people with conditions like irritable bowel syndrome or inflammatory bowel disease, to help find better ways to manage this pain and its connection to stress and mental health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11165490 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind visceral pain, particularly in conditions like irritable bowel syndrome and inflammatory bowel disease. It focuses on specific neurons in the spinal cord that may play a crucial role in how visceral pain is processed and perceived. By studying these neural circuits, the research aims to uncover new insights into the relationship between visceral pain and stress-related psychiatric disorders. The findings could lead to better clinical management strategies for patients suffering from chronic visceral pain.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with functional gastrointestinal disorders such as IBS or IBD, particularly those experiencing chronic visceral pain.
Not a fit: Patients with acute gastrointestinal issues or those not experiencing chronic visceral pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from chronic visceral pain and related psychiatric disorders.
How similar studies have performed: Previous studies have shown promise in understanding the neural mechanisms of visceral pain, suggesting that this research could build on established findings.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Hu, Hongzhen — Icahn School of Medicine at Mount Sinai
- Study coordinator: Hu, Hongzhen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.