Understanding how spinal circuits control precise limb movements
Spinal Circuits for the Control of Dextrous Movement
['FUNDING_OTHER'] · SALK INSTITUTE FOR BIOLOGICAL STUDIES · NIH-10696186
This study is looking at how certain nerve cells in the spinal cord help control the smooth and precise movements of our arms and hands, using mice to learn more about how these cells work together with signals from the brain and senses, which could eventually help us understand movement better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SALK INSTITUTE FOR BIOLOGICAL STUDIES (nih funded) |
| Locations | 1 site (La Jolla, UNITED STATES) |
| Trial ID | NIH-10696186 on ClinicalTrials.gov |
What this research studies
This research investigates the local networks within the spinal cord that are crucial for controlling dexterous movements of the limbs. By utilizing advanced genetic tools in mice, the study aims to map out the specific types of neurons involved in these motor behaviors and how they interact with sensory inputs and brain signals. The researchers will create a detailed atlas of forelimb-related interneurons in the cervical spinal cord, which will help in understanding the coordination of movements. This work could lead to predictive models that explain how these networks function and are regulated.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that impair dexterous limb movements, such as spinal cord injuries or neurological disorders.
Not a fit: Patients with conditions unrelated to spinal cord function or those who do not experience motor control issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of motor control, potentially leading to improved treatments for conditions affecting limb movement.
How similar studies have performed: Other research has shown success in mapping spinal circuits and understanding motor control, indicating that this approach has a foundation in prior findings.
Where this research is happening
La Jolla, UNITED STATES
- SALK INSTITUTE FOR BIOLOGICAL STUDIES — La Jolla, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOULDING, MARTYN D — SALK INSTITUTE FOR BIOLOGICAL STUDIES
- Study coordinator: GOULDING, MARTYN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.