Understanding how spinal circuits control movement
Interneuron circuits in the spinal motor system
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11066488
This study is looking at special nerve cells in the spinal cord that help control how our muscles move, and it's for anyone interested in understanding how these cells work and how they might be linked to movement problems in conditions like spinal injuries or neurological disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11066488 on ClinicalTrials.gov |
What this research studies
This research investigates the complex neural circuits in the spinal cord that are responsible for controlling muscle contractions and movement. By focusing on a specific type of spinal interneuron known as V1 interneurons, the study aims to uncover how these cells contribute to motor output and behavior. The researchers will analyze the molecular characteristics and electrical properties of different subsets of V1 interneurons to better understand their roles in movement. This knowledge could lead to insights into how spinal circuits function and how they might be affected in various neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who may be experiencing motor control issues or degenerative neurological diseases.
Not a fit: Patients with non-neurological conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of motor control and potentially lead to new treatments for movement disorders.
How similar studies have performed: Other research has shown promise in understanding spinal circuits, but this specific focus on V1 interneuron diversity is relatively novel.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BIKOFF, JAY BENJAMIN — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: BIKOFF, JAY BENJAMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.