Understanding how sphingolipids affect mitochondrial health
Sphingolipid signaling in mitochondrial surveillance
This study is looking at how a specific fat molecule called sphingosine-1-phosphate (S1P) affects the energy factories in our cells, especially in nerve cells, and how they respond to stress, using tiny worms as a model, to help us understand more about diseases related to cell energy problems, like some cancers and heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10683149 on NIH RePORTER |
What this research studies
This research investigates the role of sphingolipids, specifically sphingosine-1-phosphate (S1P), in regulating mitochondrial function and stress responses. Using the model organism C. elegans, the study aims to uncover how sphingolipid signaling influences neuronal function and the activation of the mitochondrial unfolded protein response (UPRmt). By exploring the molecular mechanisms involved, the research seeks to provide insights into how these processes affect cellular health and resilience against stress. The findings could lead to a better understanding of diseases linked to mitochondrial dysfunction, including certain cancers and cardiovascular disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or cardiovascular diseases that may be linked to mitochondrial dysfunction.
Not a fit: Patients with conditions unrelated to mitochondrial function or sphingolipid signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and cardiovascular diseases by targeting mitochondrial health.
How similar studies have performed: Previous research has shown promising results in understanding sphingolipid signaling and its implications for cellular health, indicating that this approach has potential for significant findings.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Sieburth, Derek — University of Southern California
- Study coordinator: Sieburth, Derek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.