Understanding How Sperm Stem Cells Develop
Spermatogonial Stem Cell Establishment and Regulation
This research explores how sperm stem cells are formed and regulated, which could help men facing infertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11145060 on NIH RePORTER |
What this research studies
Spermatogonial stem cells (SSCs) are special cells that continuously produce sperm throughout a man's life. This project aims to understand how these crucial cells are initially formed and how they maintain themselves. Researchers are looking at specific genetic switches, called transcription factors, that control the development of these stem cells. They are also investigating how these cells react to genetic problems, which could offer insights into how human sperm stem cells respond to harmful treatments like cancer therapy. The ultimate goal is to find new ways to help men who cannot have children due to infertility.
Who could benefit from this research
Good fit: This basic science research is foundational for future treatments for men experiencing infertility, particularly those whose fertility has been impacted by cancer treatments.
Not a fit: Patients whose infertility is not related to spermatogonial stem cell function or establishment may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for male infertility, especially for those affected by cancer treatments or genetic issues.
How similar studies have performed: This research builds upon the researchers' own novel discoveries regarding specific genetic factors that influence sperm stem cell development.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Wilkinson, Miles Frome — University of California, San Diego
- Study coordinator: Wilkinson, Miles Frome
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.