Understanding how sperm channels affect fertility
CatSper regulation of sperm physiology and fertility
This study is looking at how a special channel in sperm, called CatSper, helps control calcium levels that are important for sperm movement and fertilization, with the goal of finding new ways to help men who are having trouble with fertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11077370 on NIH RePORTER |
What this research studies
This research investigates the role of the CatSper channel in sperm physiology, focusing on how it regulates calcium signaling essential for sperm motility and successful fertilization. By using advanced imaging techniques and animal models, the study aims to uncover the molecular mechanisms behind sperm function and fertility. The research also explores how CatSper interacts with other signaling pathways to maintain calcium homeostasis in sperm. Insights gained from this research could lead to new approaches in treating male infertility.
Who could benefit from this research
Good fit: Ideal candidates for this research are men experiencing infertility issues related to sperm motility or function.
Not a fit: Patients with infertility not related to sperm physiology or those with non-male reproductive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for male infertility by enhancing our understanding of sperm function.
How similar studies have performed: Previous studies have shown promising results in understanding sperm physiology through similar molecular and imaging approaches.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Chung, Jean-Ju Lucia — Yale University
- Study coordinator: Chung, Jean-Ju Lucia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.