Understanding how sperm cells become activated in a tiny worm.
Official title: Regulation of sperm activation in C. elegans
Funded at St. John's University · NIH-10937195 · Data updated 2026-11-12
This study looks at how sperm in tiny worms called C. elegans get ready to swim and fertilize eggs, aiming to understand the genes and signals that help this process, which could also shed light on fertility problems in other animals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. John's University NIH-funded |
| Lab location | 1 site (Queens, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $180,500 |
| NIH project number | 1R16GM154785-01 |
| Project ID | NIH-10937195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing difficulties with conception or fertility issues.
✕Less likely to help
Patients who are not experiencing fertility problems or who are not seeking to conceive may not benefit from this research.
What this research studies
This research investigates the process of sperm activation in the nematode C. elegans, focusing on how sperm cells undergo significant changes to become motile and capable of fertilization. The study examines the genetic and molecular mechanisms that regulate this transformation, particularly the role of signaling pathways and proteins involved in sperm development. By exploring these processes, the research aims to uncover the underlying factors that contribute to successful fertilization. This work is particularly relevant as it may provide insights into fertility issues in other organisms.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of fertility mechanisms, potentially leading to new treatments for infertility.
How similar studies have gone: While the specific mechanisms in C. elegans are being explored, similar research in other organisms has shown promise in understanding fertility, indicating potential for success.
Where this research is happening
-
St. John's University
Queens, United States Active
Researchers
- Principal investigator: Mei, Xue — St. John's University
- Study coordinator: Mei, Xue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.