Understanding how specific T cells help fight lung viral infections
Control of Humoral and Cellular Immunity to Viral Infections of the Lung by Follicular CD8 T Cells
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11043373
This study is looking at a special type of immune cell that helps fight off viral infections in the lungs, and it aims to learn how these cells work with other immune cells to boost our body's defense against respiratory viruses, which could lead to better treatments and vaccines for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11043373 on ClinicalTrials.gov |
What this research studies
This research investigates a unique type of T cell, known as CXCR5+ CD8 T cells, which play a crucial role in the immune response to viral infections in the lungs. The study aims to understand how these T cells interact with B cells to regulate both antibody production and cellular immunity during acute respiratory infections. By exploring the mechanisms that control the functions of these T cells, the research seeks to uncover new insights into how the immune system can effectively combat viral infections. Patients may benefit from this research as it could lead to improved treatments and vaccines for respiratory viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing acute respiratory infections, particularly those caused by viral pathogens.
Not a fit: Patients with chronic lung diseases unrelated to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to enhanced strategies for preventing and treating viral infections of the lung.
How similar studies have performed: Previous research has shown promise in understanding T cell interactions in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAGE, PETER THE — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: SAGE, PETER THE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection, Acute respiratory infection