Understanding how specific T cell subsets influence allergic diseases
Humoral Immunoregulation of Allergic Disease by Follicular T Cell Subsets
This study is looking at how certain immune cells called T follicular helper and T follicular regulatory cells work together to control allergic reactions, with the hope of finding new ways to treat allergies by targeting the bad responses in the immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11026415 on NIH RePORTER |
What this research studies
This research investigates the role of different subsets of T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in regulating allergic inflammation. By using innovative mouse models, the study aims to uncover how these T cell subsets interact with B cells and influence the immune response during allergic reactions. The researchers will explore the balance between stimulatory and inhibitory signals that these cells provide, which is crucial for understanding the development of allergic diseases. The ultimate goal is to identify new therapeutic strategies that can selectively target harmful antibody responses in allergies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from allergic diseases, particularly those with severe allergic inflammation.
Not a fit: Patients with non-allergic conditions or those whose allergies are not mediated by Tfh and Tfr cell interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically mitigate allergic responses without compromising overall immune function.
How similar studies have performed: Previous research has shown promising results in understanding T cell roles in allergies, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sage, Peter the — Brigham and Women's Hospital
- Study coordinator: Sage, Peter the
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.