Understanding how specific T cell responses affect liver disease
Official title: Defining the role of antigen-specific T cell responses in NASH
Funded at University of Colorado Denver · NIH-11170150 · Data updated 2026-11-12
This study is looking at how certain immune cells called T cells behave in people and animals with Non-Alcoholic Steatohepatitis (NASH) to find new ways to treat this liver disease, which could help patients manage their condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 15, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $599,541 |
| NIH project number | 1R56DK135533-01A1 |
| Project ID | NIH-11170150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Non-Alcoholic Steatohepatitis (NASH) or those at risk due to obesity or alcohol consumption.
✕Less likely to help
Patients with liver diseases unrelated to NASH or those who do not have significant T cell involvement may not benefit from this research.
What this research studies
This research investigates the role of antigen-specific T cell responses in Non-Alcoholic Steatohepatitis (NASH), a chronic liver disease. By examining both human and animal models, the study aims to uncover how T cell activation and clonal expansion contribute to the progression of NASH. The researchers will analyze T lymphocyte behavior in the liver to identify potential therapeutic targets that could lead to new treatments for this condition. Patients may benefit from insights that could lead to innovative therapies for managing NASH.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from NASH and related liver diseases.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Burchill, Matthew a — University of Colorado Denver
- Study coordinator: Burchill, Matthew a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.