Understanding how specific skin cells affect fibrosing skin diseases
Official title: Defining the role of Pi16-expressing fibroblasts in mouse and human fibrosing skin disease
Funded at University of California, San Francisco · NIH-11033106 · Data updated 2026-11-12
This study is looking at a special type of skin cell to understand how it affects skin diseases that cause thickening and scarring, and it hopes to find new ways to help people with these conditions feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $176,148 |
| NIH project number | 1K08AR085193-01 |
| Project ID | NIH-11033106 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from fibrosing skin diseases or related conditions.
✕Less likely to help
Patients with non-fibrosing skin conditions or those not affected by skin diseases may not benefit from this research.
What this research studies
This research investigates the role of a specific type of skin cell, known as Pi16-expressing fibroblasts, in the development and progression of fibrosing skin diseases. The study will utilize advanced techniques, including genetic manipulation and transcriptomic analysis, to explore how these fibroblasts respond to fibrotic stimuli and their potential to mitigate fibrosis. By examining both mouse models and human samples, the research aims to uncover the underlying mechanisms that govern skin health and disease. Patients may benefit from insights that could lead to new therapeutic strategies for managing fibrosing skin conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with fibrosing skin diseases.
How similar studies have gone: Previous research has shown promise in understanding fibroblast roles in fibrosis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kinet, Maxime Jeremie — University of California, San Francisco
- Study coordinator: Kinet, Maxime Jeremie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.