Understanding how specific signals affect lung development
Uncovering the mesenchyme-specific roles of planar cell polarity in lung development
['FUNDING_R01'] · PRINCETON UNIVERSITY · NIH-11048444
This study looks at how certain signals in the body help develop healthy lungs, especially how a special type of tissue affects the tiny air sacs we need for breathing, and it aims to find out what might go wrong in premature babies that can cause lung problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-11048444 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific cellular signals in the development of the lungs, particularly focusing on how the mesenchyme, a type of connective tissue, influences the formation of alveoli, which are essential for breathing. By studying the interactions between different cell types during lung development, the researchers aim to identify mechanisms that could be disrupted in premature infants, leading to lung function issues. The approach includes advanced imaging techniques and genetically modified mice to observe these processes in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who were born prematurely and may have experienced lung development complications.
Not a fit: Patients who are adults without a history of premature birth or lung development issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for lung development issues in premature infants, potentially improving their long-term respiratory health.
How similar studies have performed: Other research has shown promising results in understanding cellular signaling pathways in lung development, indicating that this approach has potential for success.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NELSON, CELESTE M — PRINCETON UNIVERSITY
- Study coordinator: NELSON, CELESTE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.