Understanding how specific signaling pathways affect stem cell behavior and development
Dissecting mechanistic links between MAPK signaling, genomic hypomethylation and naive pluripotency
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11057610
This study is looking at how certain signals and changes in DNA affect stem cells, which are important for creating all types of cells in our bodies, to see if we can make them more useful for future treatments, especially by understanding how female cells are different.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11057610 on ClinicalTrials.gov |
What this research studies
This research investigates the role of MAPK signaling and genomic hypomethylation in embryonic stem cells (ESCs), which are crucial for developing all cell types in the body. By using specific inhibitors, the study aims to recreate a state of ESCs that resembles early embryonic development, allowing researchers to explore how these cells can be manipulated for therapeutic purposes. The research also examines how sex chromosomes influence methylation patterns in female ESCs, which may have implications for understanding developmental processes. Through this work, the researchers hope to uncover mechanisms that could enhance the stability and potential of stem cells for future medical applications.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions that could be treated using stem cell therapies.
Not a fit: Patients with conditions unrelated to stem cell therapy or those not eligible for stem cell treatments may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for generating stable and versatile stem cells for regenerative medicine.
How similar studies have performed: Previous research has shown promising results in manipulating stem cell states, indicating that this approach may lead to significant advancements in the field.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOCHEDLINGER, KONRAD — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: HOCHEDLINGER, KONRAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.