Understanding how specific signaling at nerve connections responds to electrical changes
Investigating the function of localized BMP signaling at neuromuscular synapses
['FUNDING_R15'] · SOUTHERN CONNECTICUT STATE UNIVERSITY · NIH-10292139
This study is looking at how certain signals in the brain, called BMP signals, change when nerve cells get excited, using fruit flies to help us understand how these signals affect communication between nerve cells, which is important for learning more about brain health and diseases.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTHERN CONNECTICUT STATE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10292139 on ClinicalTrials.gov |
What this research studies
This research investigates the role of localized bone morphogenetic protein (BMP) signaling at neuromuscular synapses, focusing on how these signals respond to changes in membrane voltage. Using the fruit fly Drosophila melanogaster as a model organism, the study aims to uncover the mechanisms that link electrical activity to cellular responses at synapses. By examining how BMP signaling adapts to voltage changes, the research seeks to provide insights into synaptic transmission, which is crucial for understanding neurological and neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those affected by Alzheimer's disease.
Not a fit: Patients with acute neurological injuries or those not diagnosed with neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of synaptic transmission, potentially informing treatments for neurodegenerative diseases like Alzheimer's.
How similar studies have performed: While the specific approach of localized BMP signaling in this context is novel, similar studies have shown promise in understanding synaptic mechanisms in other models.
Where this research is happening
NEW HAVEN, UNITED STATES
- SOUTHERN CONNECTICUT STATE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SULKOWSKI, MIKOLAJ — SOUTHERN CONNECTICUT STATE UNIVERSITY
- Study coordinator: SULKOWSKI, MIKOLAJ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease