Understanding how specific sequences and factors regulate protein production
Regulation of mRNA translation by cis-acting sequences and trans-acting factors
This study is looking at how certain parts of our genes help control the production of proteins, which is important for understanding diseases, and it’s designed for anyone interested in how genetic changes can affect health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11065428 on NIH RePORTER |
What this research studies
This research investigates the regulation of mRNA translation, which is crucial for protein production and understanding human diseases. The team will explore how certain sequences in genes and RNA-binding proteins influence this process. By using advanced techniques in human tissue culture and computational modeling, they aim to uncover the functions of upstream open reading frames (uORFs) and their role in gene regulation. This could lead to better insights into the relationship between genetic mutations and disease outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders that may involve dysregulation of protein production.
Not a fit: Patients with conditions unrelated to mRNA translation or protein production may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation and lead to improved treatments for diseases linked to protein production errors.
How similar studies have performed: Other research has shown promising results in understanding gene regulation through similar approaches, indicating potential for success in this area.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Mcmanus, Charles Joel — Carnegie-Mellon University
- Study coordinator: Mcmanus, Charles Joel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.