Understanding how specific RNA structures affect nerve pain signals
Official title: Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds
Funded at Saint Louis University · NIH-11053574 · Data updated 2026-11-12
This study is looking at how certain changes in nerve cells might affect chronic pain and hopes to find new ways to help manage that pain by focusing on special RNA structures, which could lead to better treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $227,250 |
| NIH project number | 5R21NS137054-02 |
| Project ID | NIH-11053574 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic neuropathic pain.
✕Less likely to help
Patients with acute pain conditions or those not experiencing neuropathic pain may not benefit from this research.
What this research studies
This research investigates the molecular changes in nerve cells that occur during chronic neuropathic pain. It focuses on how certain RNA structures, known as G-quadruplexes, influence the movement of genetic information at the synapse, which is crucial for nerve signaling. By mapping these changes, the study aims to uncover the underlying mechanisms of neuropathic pain and explore new treatment strategies that target these RNA structures. Patients may benefit from insights that could lead to innovative therapies for managing their pain.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic neuropathic pain, improving the quality of life for affected patients.
How similar studies have gone: While the specific approach of targeting G-quadruplexes in neuropathic pain is novel, similar research has shown promise in understanding RNA structures in other conditions.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Francois Ep Moutal, Liberty — Saint Louis University
- Study coordinator: Francois Ep Moutal, Liberty
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.