Understanding how specific RNA segments are spliced in neurons and their impact on autism.
Co-transcriptional mechanisms of neuronal microexon splicing: causes and consequences for 3' end processing
This study is looking at how tiny pieces of RNA, important for brain development, are put together and how mistakes in this process might be linked to autism, using advanced techniques to better understand these connections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10908487 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the splicing of microexons, which are short segments of RNA crucial for neuronal development. It focuses on how these microexons are processed during transcription and how their mis-splicing may contribute to autism spectrum disorder. The study employs advanced sequencing techniques to analyze the relationship between microexon splicing and transcription elongation, aiming to uncover the regulatory processes involved. By examining single molecules of mRNA, the research seeks to clarify the interactions between microexon splicing and other RNA processing events.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with known splicing abnormalities.
Not a fit: Patients without a diagnosis of autism spectrum disorder or those not exhibiting splicing-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the molecular causes of autism, potentially informing future therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding RNA splicing mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Gordon, Jackson — Yale University
- Study coordinator: Gordon, Jackson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.