Understanding how specific RNA molecules affect male fertility.
Official title: Genetic and biochemical dissection of mammalian pachytene piRNA biogenesis.
Funded at Michigan State University · NIH-11010981 · Data updated 2026-11-12
This study is looking at a special type of RNA that helps with male fertility in mice, to learn how it works and how it might lead to better treatments for men facing infertility issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | January 9, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $423,036 |
| NIH project number | 1R35GM156209-01 |
| Project ID | NIH-11010981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men experiencing infertility or difficulties conceiving.
✕Less likely to help
Patients with infertility not related to male germ cell function may not benefit from this research.
What this research studies
This research investigates the role of pachytene piRNAs, a type of RNA crucial for male fertility, by examining how they are produced and function in germ cells. The study combines genetic and biochemical techniques in mice to explore the mechanisms behind piRNA biogenesis and its impact on spermatogenesis. By understanding these processes, the research aims to uncover new insights into male infertility and potential treatments. Patients may benefit from advancements in fertility treatments based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating male infertility.
How similar studies have gone: While the specific focus on pachytene piRNAs is novel, related research on RNA's role in fertility has shown promising results.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Chen, Chen — Michigan State University
- Study coordinator: Chen, Chen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.